Chinese scientists a way to get from corn selective anti HIV protease mutant infected cells, the development of new anti-HIV drugs provide new ideas and new strategies.
It is here today from the Kunming Institute of Zoology Chinese Academy of Sciences outgoing messages. Yunnan Province, adjacent to many countries in Southeast Asia was China's drug and AIDS-stricken area.
Sources said, the CAS Kunming Institute of Zoology ZHENG Yong-tang academic researcher with the Hong Kong Chinese University Research Group Professor Shao Pengzhu this research collaboration.
ZHENG Yong-Tang researchers in immunology, virology and anti-HIV drugs of more than 20 years, especially in the anti-HIV drugs, AIDS primate model, such as limiting factors of the virus has accumulated rich experience.
He said, "HIV virus in the hidden mechanisms of long-term potential in the cell and escape the host immune system attack, the current anti-HIV drugs listed are not selectively killing infected cells and eradicate the virus, and research
Studies with selective anti-HIV infected cells to protect normal cells from harm anti-HIV drugs is extremely important. "
After years of cooperation, the Mainland and Hong Kong scientists maize ribosome inactivating protein inactivation domain of the internal structure of a series of modification and transformation, access to HIV protease to recognize and activate specific maize ribosomal
Inactivation mutant.
Experimental studies have shown that the cellular level, such mutant cells are not infected with low toxicity, but the mutants into HIV infected cells, it can be identified within the cell and cut to remove HIV protease inactivation domain transformed into
Active protein, thereby selectively killing HIV infected cells. The results also show that because of this mutant to efficiently enter the infected cell, so HIV-1 infected cells in the deadlier germs; mutants can
HIV protease drug-resistant strains were identified and activate the protease, the protease resistant mutant strains of HIV infected cells also have a good selection of destruction.
ZHENG Yong-Tang said the study results specific target HIV infected cells developed a new type of anti-HIV drugs provide new ideas and new strategies. "Research results have been well-known in international academic journals" Nucleic Acids
Research "published and national patent applications. "
Cheng said the study received the Research Grants Council of Hong Kong, China 973 projects, major national science and technology projects and other projects funded Chinese Academy of Sciences.