Study discovery raises immune system to balance the new method of ability

The scientists of the Jonsson cancer center that comes from UCLA discovered a kind to refuse access of phlogistic cell signal brand-newly recently, this is the principal mechanism that holds immune reaction to be balanced accurately probably.

  studies the result was published June " Cell " go up, the hematology of UCLA and oncology are taught, article Ke Shuai of the first author thinks, study achievement will bring the method of new remedial cancer and inflammation reaction disease.

  Shuai expresses: "The significant gain of research depended on discovering the new cellular way that restricts inflammation and immunity. It is very important to immune system is affected to antagonism cause of disease and kill tumor cell. This one discovery can help us design new adjustment the medicaments of immune system. This one discovery can help us design new adjustment the medicaments of immune system..

  Shuai and colleague discovered this kind of PIAS1 fights phlogistic way, this is one kind often is used by extensive exciter intercessory immunity system and the way that touchs inflammation disease. Inflammation is the natural defence that a kind of antagonism of the body affects, but lopsided inflammation will make people suffers from more easily on the disease such as cancer.

Method of   PIAS1 helps the healthy balance that maintains immune system. When encountering bacterium and other menace, gene of important immune adjusting control will be started in nucleolus affect in order to defy. Shuai and colleague discover, PIAS1 can stop the production of gene of immune adjusting control, produce excessive inflammation in order to prevent to react.

  is in when producing cancer, immune system can be aroused to rise kill cancer cell, this can help research and development fight cancerous vaccine. Accordingly, a kind can the medicaments of abate PIAS1 method can be used at enhancing action of cancer of immune system antagonism. Besides, this kind of medicaments still can defy other is important disease, for example HIV.

The research group of   Shuai plans next is to consider to use miniaturization to learn an element to come action at PIAS1 signal access, achieve the result that treats cancer and other disease thereby.